The crash reportedly happened when a driver tried to change lanes and rear-ended another vehicle, leading to a stack of four vehicles in total, reports say.
The first driver hit sustained fatal injuries as a result of the direct impact. Their identity is not being released at this time.
The accident occurred shortly before 7 p.m., just south of the Spring Street on-ramp. CHP closed Highway 101 Southbound and set up a detour using Spring and Vine Streets.
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